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Study finds pregnancy hormone may offer cure for MS


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The Founder
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Study finds pregnancy hormone may offer cure for MS

Study finds pregnancy hormone may offer cure for multiple sclerosis

A hormone produced when women are pregnant could hold a vital clue in the successful treatment of the debilitating disease multiple sclerosis, scientists believe.

Researchers at the University of Calgary in Canada have identified a pregnancy-related hormone, which they say rebuilds a protective coating around nerve cells, which get damaged in the disease.

In experiments conducted on mice at the university's faculty of medicine, the scientists found that prolactin, a hormone produced in large measures during pregnancy, spurs spontaneous production of myelin, a fatty substance that gives the protective coating to the nerve cells. This process, the scientists believe, can repair the damaged nerve cells responsible for the symptoms in multiple sclerosis, a condition resulting from the body's immune system turning on itself, attacking myelin.

The research was triggered when scientists observed that multiple sclerosis usually tends to go into remission during pregnancy.

The study, a collaborative effort between scientist teams of Dr Samuel Weiss and Dr V Wee Yong of the Hotchkiss Brain Institute, revealed that prolactin, the levels of which go up during pregnancy, is responsible for creation of myelin in the brain and spinal cords. The scientists, in their experiments with mice, injected prolactin in non-pregnant mice with multiple sclerosis and found that their myelin was repaired.

During the study, the scientists compared pregnant and non-pregnant mice of the same age group and found that pregnant mice had twice as many myelin-producing cells and these continued to generate new ones during pregnancy compared with non-pregnant mice. When they destroyed the myelin around nerve cells of these mice, they found that pregnant mice had twice as much new myelin two weeks following the act as non-pregnant mice and injection of prolactin led to myelin production and repair in the non-pregnant mice.

Weiss, director of the Hotchkiss Brain Institute, who authored a paper on the research along with other members of the research team, said it is thought that during pregnancy, women's immune system no longer destroyed the myelin. However, no previous study has tested whether pregnancy actually results in the production of new myelin, which may lead to improvement in the symptoms of the disease.

The details of the research are published in the Journal of Neuroscience.

Weiss said before trials on both men and women could start, there is need for more animal testing.

Post Mon 26 Feb, 2007 6:28 pm 
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brendya
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Joined: 27 Apr 2009
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How long after a miscarriage will a home pregnancy test be accurate?
I was 7 weeks along when I had a miscarriage, everything was natural, no d&c. It has been about 5 weeks since the start of the miscarriage (it lasted about a week) I took 2 home pregnancy tests yesterday and they both came out positive, could this be because my hcg levels are still up from the miscarriage or is it more likely that I am pregnant?
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Post Wed 29 Apr, 2009 2:32 am 
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PaulaJane
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I was diagnosed with MS in 2005. I went online and found a nutrient that feeds the cells the nutrient we can no longer get in our foods. I took it only as suggested. My dr that diagnosed me told me that I no longer have MS. Strange? It makes me wonder if I really did have MS. Was it just a way to make money off of me?
At the time when I told my dr that I was doing a nutrient instead of the drugs, he asked me what it was and stated that he had 2 other patients doing the same. His concern was the cost of the nutrient. I mentioned to him the cost of the nutrient was much much less than the MS drugs. I wished I had worded it better because that was the end of the conversation.

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Post Sun 19 Jul, 2009 11:47 pm 
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